RNS Number : 8933D

Roquefort Therapeutics PLC

26 June 2023

Roquefort Therapeutics plc

("Roquefort Therapeutics" or the "Company")

Director/PDMR Shareholding

Roquefort Therapeutics (LSE:ROQ, OTCQB:ROQAF), the Main Market listed biotech company focused on developing first in class drugs in the high value and high growth oncology segment, advises that Stephen West, Executive Chairman has purchased ordinary shares in the Company, as detailed below:

Number of Ordinary Shares	Average Price Paid Per Share	Total Consideration Paid
144,117	6.9 pence	£9,942.49

Following the above purchase of shares, Stephen West holds an interest in 5,457,381 Company ordinary shares and 7,000,000 warrants. 4,628,485 of Mr West's shares are held in the name of Cresthaven Investments Pty Ltd ATF the Bellini Trust.

-ENDS-

Enquiries:

Roquefort Therapeutics plc

Stephen West (Chairman) / Ajan Reginald (CEO)

+44 (0)20 3918 8633

Hybridan LLP (Joint Broker)

Claire Louise Noyce

Optiva Securities Limited (Joint Broker)

+44 (0)203 764 2341

Christian Dennis

Buchanan (Public Relations)

Ben Romney / Jamie Hooper / George Beale

+44 (0)20 3411 1881

+44 (0)20 7466 5000

LEI: ‎254900P4SISIWOR9RH34

About Roquefort Therapeutics

Roquefort Therapeutics (LSE:ROQ, OTCQB:ROQAF) is a Main Market listed biotech company developing first in class drugs in the high value and high growth oncology segment prior to partnering or selling to big pharma.

Since listing in March 2021, Roquefort Therapeutics has successfully acquired Lyramid Pty Limited, a leader in the development of medicines for a new therapeutic target, Midkine (a human growth factor associated with cancer progression), and most recently acquired Oncogeni Ltd, founded by Nobel Laureate Professor Sir Martin Evans, which has developed two families of innovative cell and RNA oncology medicines.

Roquefort Therapeutics' portfolio consists of five fully funded, novel patent-protected pre-clinical anti-cancer medicines. The highly complementary profile of five best-in-class medicines consists of:

· Midkine antibodies with significant in vivo efficacy and toxicology studies;

· Midkine RNA therapeutics with novel anti-cancer gene editing action;

· Midkine mRNA therapeutics with novel anti-cancer approach;

· STAT-6 siRNA therapeutics targeting solid tumours with significant in vivo efficacy; and

· MK cell therapy with direct and NK-mediated anti-cancer action

For further information on Roquefort Therapeutics, please visit www.roquefortplc.com and @RoquefortTherap on Twitter.

This announcement contains inside information for the purposes of Article 7 of the UK version of Market Regulation (EU) No 596/2014 on Market Abuse as it forms part of UK domestic law by virtue of the European Union (Withdrawal) Act 2018, as amended ("UK MAR").

The notification below, made in accordance with the requirements of the UK MAR, provides further detail:

NOTIFICATION AND PUBLIC DISCLOSURE OF TRANSACTIONS BY PERSONS DISCHARGING MANAGERIAL RESPONSIBILITIES AND PERSONS CLOSELY ASSOCIATED WITH THEM

1	Details of the person discharging managerial responsibilities / person closely associated
a)	Name	Stephen West
2	Reason for the notification
a)	Position/status	Executive Chairman
b)	Initial notification /Amendment	Initial
3	Details of the issuer, emission allowance market participant, auction platform, auctioneer or auction monitor
a)	Name	Roquefort Therapeutics plc
b)	LEI	254900P4SISIWOR9RH34
4	Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducted
a)	Description of the financial instrument, type of instrument Identification code	Ordinary shares of £0.01 par value ISIN: GB00BMDQ2T15
b)	Nature of the transaction	Purchase of 144,117 ordinary shares
c)	Price(s) and volume(s)	Price(s)	Volume(s)
		6.90 pence per share	144,117
d	Aggregated information - Aggregated volume - Price	- 144,117 - 6.90p
e)	Date of the transactions	26 June 2023
f)	Place of the transactions	London Stock Exchange (XLON); Main Market

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